Thermo Fisher Scientific GPR120 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 10–20 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Monkey, Marmoset, Mouse, Rat, Elephant, Horse, Opossum (94%)
Bat, Panda, Pig (89%)
Turkey (83%)

Target Information

An EST for GPR120 has been isolated from a human colon cancer library.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist.
All GPCRs share a structural motif consisting of seven membrane-spanning helices and exist in both active and inactive forms.
An array of activating ligands participate in the conformation of GPCRs, leading to signaling via G-proteins and downstream effectors.
Ongoing studies have shown complex reactions involved in negative regulation of GPCRs, which have significant physiological implications and drive pharmacological research for new drug candidates.
Notable GPCR-targeted drugs include Zyprexa (Eli Lilly) and Claritin (Schering-Plough), which dominate the mental health and allergy markets.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.