Thermo Fisher Scientific GRP78 Polyclonal Antibody, Alexa Fluor 488
Alexa Fluor 488으로 결합된 GRP78 폴리클로날 항체로, 인간·마우스·랫 시료에서 ER 단백질 GRP78 검출에 적합. WB, ICC/IF, Flow Cytometry 등 다양한 응용 가능. 항원 친화 크로마토그래피로 정제된 고순도 항체. 4°C 암소 보관, 동결 금지.
- 카탈로그번호
- PA1014AA488
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- pk
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Thermo Fisher Scientific GRP78 Polyclonal Antibody, Alexa Fluor 488
Applications 및 Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1–10 µg/mL | - |
| Flow Cytometry (Flow) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues C T(643) G E E D T S E K D E L(654) of rat GRP78 |
| Conjugate | Alexa Fluor™ 488 |
| Excitation / Emission Max | 499 / 520 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2662418 |
Product Specific Information
PA1-014A-A488 detects glucose regulated protein/BiP (GRP78) in human, rat, and mouse samples.
The immunogen is a synthetic peptide corresponding to residues C T(643) G E E D T S E K D E L(654) of rat GRP78.
Target Information
GRP78 (78 kDa) is a glucose-regulated protein belonging to the heat shock protein family (HSP70).
It resides in the endoplasmic reticulum (ER) and assists in folding newly synthesized secretory and membrane proteins. GRP78 also interacts with misfolded proteins, marking them for degradation.
The conserved KDEL motif (Lys-Asp-Glu-Leu) at the C-terminus ensures ER retention and recycling via the KDEL receptor.
GRP78 plays a crucial role in maintaining cell homeostasis and preventing apoptosis.
Clinical relevance includes:
- Biomarker for hypoglycemia
- Neuroprotective function under oxidative stress
- Reduced levels in Alzheimer’s Disease brains
- Association with PS1 gene mutations
- Induction linked to antitumor drug resistance
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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