Thermo Fisher Scientific GRP78 Polyclonal Antibody, Alexa Fluor 555
Alexa Fluor 555로 표지된 GRP78 폴리클로날 항체로, 인간·마우스·랫트 시료에서 GRP78 단백질 검출에 적합합니다. Western blot 및 면역세포화학(ICC/IF)에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 형광 최대치 553/568 nm.
- 카탈로그번호
- PA1014AA555
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested dilution: Not specified
- View 1 publication
Immunocytochemistry (ICC/IF)
- Tested dilution: 1–10 µg/mL
- View references
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues C T(643) G E E D T S E K D E L(654) of rat GRP78 |
| Conjugate | Alexa Fluor™ 555 |
| Excitation / Emission Max | 553 / 568 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2662646 |
Product Specific Information
PA1-014A-A555 detects glucose regulated protein/BiP (GRP78) in human, rat, and mouse samples.
The immunogen is a synthetic peptide corresponding to residues C T(643) G E E D T S E K D E L(654) of rat GRP78.
Target Information
GRP78 is a 78 kDa glucose-regulated protein belonging to the HSP70 family. It resides in the endoplasmic reticulum (ER) and associates with newly synthesized secretory and membrane proteins.
GRP78 interacts with misfolded proteins, marking them for degradation, and contains the conserved KDEL sequence at its C-terminus, ensuring ER retention via the KDEL receptor.
It is essential for protein folding, ER homeostasis, and apoptosis prevention. GRP78 serves as a biomarker for hypoglycemia and has neuroprotective functions against oxidative stress. Reduced GRP78 levels are observed in Alzheimer's Disease, and its induction is linked to drug resistance in cancer therapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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