Thermo Fisher Scientific PIK3CG Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human PI3K gamma/Pik3cg.

Target Information

PIK3CG (p110 gamma) is the sole class IB phosphatidylinositol 3-kinase family member, which along with the class IA family members, generates the important second messenger PIP2. Unlike class IA enzymes that signal downstream of receptor tyrosine kinases, PIK3CG primarily signals downstream of GPCRs. The gene product phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring and modulates extracellular signals, including those from E-cadherin-mediated cell-cell adhesion, essential for epithelial integrity. It also plays a pivotal role in regulating cytotoxicity in NK cells and is located in a commonly deleted segment of chromosome 7 associated with myeloid leukemias.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.