Thermo Fisher Scientific RAB5 Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 1:1,000–1:4,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human RAB5.

Target Information

RAB5 belongs to the small GTPase Rab family, which are key regulators of intracellular membrane trafficking — from vesicle formation to membrane fusion.
Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that recruits downstream effectors responsible for vesicle formation, movement, tethering, and fusion.
RAB5A is required for the fusion of plasma membranes and early endosomes, contributes to filopodia extension, and regulates the exosomal release of SDCBP, CD63, PDCD6IP, and syndecan. It also plays a role in the maturation of apoptotic cell-containing phagosomes, likely downstream of DYN2 and PIK3C3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.