Thermo Fisher Scientific RAB5 Polyclonal Antibody
Human RAB5 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:1,000–1:4,000 희석으로 사용 가능. 보존제가 없는 액상 형태이며, 단백질 A 및 항원 친화 크로마토그래피로 정제됨. 세포막 융합 및 엔도솜 조절 연구에 적합.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:1,000–1:4,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the human RAB5A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788740 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human RAB5.
Target Information
RAB5 belongs to the small GTPase Rab family, which are key regulators of intracellular membrane trafficking — from vesicle formation to membrane fusion.
Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that recruits downstream effectors responsible for vesicle formation, movement, tethering, and fusion.
RAB5A is required for the fusion of plasma membranes and early endosomes, contributes to filopodia extension, and regulates the exosomal release of SDCBP, CD63, PDCD6IP, and syndecan. It also plays a role in the maturation of apoptotic cell-containing phagosomes, likely downstream of DYN2 and PIK3C3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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