Thermo Fisher Scientific CD21 Monoclonal Antibody (CR2, 2754)
CD21 단백질을 인식하는 Mouse monoclonal antibody로 다양한 응용 분야(WB, IHC, ICC/IF, Flow Cytometry)에 사용 가능. Human 반응성, Protein A/G 정제, PBS buffer에 보존. CR2 (aa 142-240) 항원을 기반으로 제작되어 EBV 및 면역 관련 연구에 적합.
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Thermo Fisher Scientific CD21 Monoclonal Antibody (CR2, 2754)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CR2, 2754 |
| Immunogen | Recombinant fragment (around aa 142–240) of human CR2 (CD21) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is tested in direct ELISA.
- For Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes.
Target Information
CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen.
CD21 plays a key role in:
- Uptake and retention of immunocomplexes
- Survival of memory B cells
- Development and maintenance of humoral response to T-dependent antigens
It also serves as a receptor for Epstein-Barr virus and is involved in targeting prions to follicular dendritic cells. Soluble CD21 (sCD21) retains ligand-binding ability.
CD21 interacts with CD23 and associates with CD19, CD81, and Leu13 to form a signal-transduction complex involved in B cell activation.
Genetic variations in CD21 are linked to susceptibility to systemic lupus erythematosus type 9 (SLEB9).
Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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