Thermo Fisher Scientific CD21 (Mature B-Cell and Follicular Dendritic Cell Marker) Monoclonal Antibody (CR2/3247)
CD21 단백질을 인식하는 마우스 모노클론 항체로, 성숙 B세포 및 여포성 수지상세포 마커로 사용됩니다. IHC, ELISA 등 다양한 응용에 적합하며, 4°C 보관 시 안정적입니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific CD21 Monoclonal Antibody (CR2/3247)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| ELISA | Assay-dependent |
| Peptide Array | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CR2/3247 |
| Immunogen | Recombinant fragment (around aa 142–240) of human CR2 (CD21) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen.
It plays an essential role in:
- Uptake and retention of immunocomplexes
- Survival of memory B cells
- Development and maintenance of humoral response to T-dependent antigens
CD21 also serves as a receptor for Epstein-Barr virus (EBV) and is involved in targeting prions to follicular dendritic cells, accelerating neuroinvasion after peripheral exposure.
A soluble form (sCD21) retains ligand-binding ability. CD21 interacts with CD23, CD19, CD81, and Leu13, forming a signal-transduction complex for B cell activation.
Genetic variations in CD21 are associated with systemic lupus erythematosus type 9 (SLEB9).
Alternative splicing produces different isoforms of CD21.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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