Thermo Fisher Scientific AOX1 Polyclonal Antibody
AOX1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(P)에서 검증됨. 인간, 마우스, 랫트에 반응하며 148 kDa 단백질 검출. 항원 친화 크로마토그래피로 정제되었고, PBS/glycerol buffer에 보존됨. 연구용으로만 사용 가능.
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- PA536922
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in human AOX1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553817 |
Product Specific Information
This antibody detects endogenous AOX1 protein at a molecular weight of approximately 148 kDa.
Purity is greater than 95% by SDS-PAGE.
Target Information
AOX1 (Aldehyde oxidase 1) is a 1338 amino acid cytoplasmic enzyme that catalyzes the oxidation of various aldehydes, producing hydrogen peroxide. Under certain conditions, AOX1 can also generate superoxide free radicals.
Defects in oxygen radical metabolism have been associated with amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder characterized by motor neuron degeneration. AOX1 is highly expressed in the ventral horn of the spinal cord, and its gene is located in a chromosomal region linked to ALS2, suggesting AOX1 as a candidate gene for ALS2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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