Thermo Fisher Scientific MPP8 Polyclonal Antibody
Thermo Fisher Scientific의 MPP8 Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 Western blot에 적합합니다. Rabbit IgG 폴리클로날 항체로 합성 펩타이드 유래 면역원 사용. 액상 형태, 1 mg/mL 농도, -20°C 보관. 세포 내 MPHOSPH8 단백질 검출에 활용됩니다.
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Applications
- Western Blot (WB): 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MPHOSPH8 (Accession Q99549), corresponding to amino acid residues M318–R368 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853260 |
Product Specific Information
Antibody detects endogenous levels of total MPHOSPH8.
Target Information
Heterochromatin component that specifically recognizes and binds methylated Lys-9 of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416).
Mediates recruitment of the HUSH complex to H3K9me3 sites, which is required to maintain transcriptional silencing by promoting recruitment of SETDB1 and MORC2 (PubMed:26022416, PubMed:28581500).
Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites (PubMed:20871592).
Mediates down-regulation of CDH1 expression and represses L1 retrotransposons in collaboration with MORC2 and SETDB1 (PubMed:20871592, PubMed:29211708).
The HUSH complex also silences unintegrated retroviral DNA by recruitment of ZNF638 (PubMed:30487602).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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