Thermo Fisher Scientific FSTL1 Monoclonal Antibody (09)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:1,000–1:2,000

Product Specifications

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human FSTL1.

Target Information

Follistatin-like protein 1 (FSTL1) is a widely-expressed extracellular glycoprotein belonging to the osteonectin (BM-40/SPARC) family, containing both a follistatin-like and extracellular calcium-binding domain. Initially identified as a TGF-beta-inducible protein in a mouse osteoblast cell line, FSTL1 participates in various biological processes including proliferation, differentiation, apoptosis, migration, embryonic development, inflammation, angiogenesis, tumorigenesis, and immune disease pathogenesis.
Highly conserved across mammalian species and widely expressed in human tissues, FSTL1 can be upregulated by innate immune mediators such as TLR4 agonists and IL-1β via NFκB pathways to stimulate pro-inflammatory cytokine secretion (TNF-α, IL-1β, IL-6, IL-8).
Mesenchymal cells produce FSTL1, while hematopoietic cells typically do not. Macrophages and monocytes can uptake FSTL1 at inflammation sites, inducing caspase-1 activation and IL-1β processing. Overexpression of FSTL1 contributes to rheumatoid arthritis (RA) and osteoarthritis (OA), whereas decreased serum levels are associated with ovarian and endometrial carcinogenesis, affecting cell proliferation, migration, and invasion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.