Thermo Fisher Scientific FSTL1 Recombinant Rabbit Monoclonal Antibody (011)

Thermo Fisher Scientific FSTL1 Recombinant Rabbit Monoclonal Antibody (Clone 011)

Applications

• ELISA (ELISA)

Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences are cloned from immunoreactive rabbits, and individual clones are screened for optimal production.

Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to large rabbit immune repertoire

This antibody has specificity for Human FSTL1.

Target Information

Follistatin-like protein 1 (FSTL1) is a widely expressed extracellular glycoprotein belonging to the osteonectin (BM-40/SPARC) family. It contains both a follistatin-like domain and an extracellular calcium-binding domain.

Initially identified as a TGF-β-inducible protein in mouse osteoblasts, FSTL1 is involved in:

• Regulation of proliferation, differentiation, apoptosis, and migration
• Embryonic development, inflammatory response, angiogenesis, tumorigenesis, and immune disease pathogenesis

Highly conserved across mammals, FSTL1 is upregulated by innate immune mediators such as TLR4 agonists and IL-1β via NFκB pathways, stimulating pro-inflammatory cytokine expression (TNF-α, IL-1β, IL-6, IL-8).

While mesenchymal cells produce FSTL1, hematopoietic cells typically do not. At inflammation sites, macrophages and monocytes can uptake FSTL1, inducing caspase-1 activation and IL-1β processing.

Overexpression of FSTL1 contributes to rheumatoid arthritis (RA) and osteoarthritis (OA), whereas reduced serum levels are linked to ovarian and endometrial carcinogenesis, affecting cell proliferation and migration.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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