Thermo Fisher Scientific CD52 Chimeric Recombinant Human Monoclonal Antibody (Campath-1H)
인간 CD52 항원을 인식하는 재조합 인간 단일클론 항체로, 다양한 면역학적 분석에 사용 가능. HEK293 세포에서 발현된 IgG1, kappa 형이며 Protein A로 정제됨. 인간 및 원숭이 종에 반응하며, 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 5 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
| Functional Assay | Assay-dependent |
| Cytotoxicity Assay (CT) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Cynomolgus monkey, Human, Rhesus monkey |
| Host/Isotype | Human / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Campath-1H |
| Immunogen | Human lymphocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074221 |
Product Specific Information
Specificity: Recognizes human CD52 antigen, also known as CAMPATH-1. CD52 is expressed at high density on lymphocytes, monocytes, eosinophils, thymocytes, and macrophages. It is also expressed by most lymphoid-derived malignancies, although expression on myeloma cells may vary.
Target Information
CD52, also known as CAMPATH-1 antigen, is a glycoprotein expressed on the surface of T and B lymphocytes, natural killer cells, and monocytes. It plays a role in immune response regulation and is studied as a therapeutic target in diseases such as multiple sclerosis, chronic lymphocytic leukemia, and autoimmune disorders. CD52 is the target of alemtuzumab, a monoclonal antibody used to deplete CD52-expressing immune cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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