Thermo Fisher Scientific CD40 Recombinant Mouse Monoclonal Antibody (G28.5)
CD40 단백질을 인식하는 마우스 유래 재조합 단클론 항체로, 인간 시료에 반응합니다. Flow cytometry, IHC, IP, T-cell activation 등 다양한 면역학적 분석에 사용 가능합니다. 고순도 Protein A 정제, 액상 형태로 제공되며 장기 보관 시 -20°C에서 안정적입니다.
✨AI 추천 연관 상품
AI가 분석한 이 상품과 연관된 추천 상품들을 확인해보세요
연관 상품을 찾고 있습니다...
Applications
Immunohistochemistry (IHC)
- Tested Dilution: Assay-dependent
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
T-Cell Activation (TCA)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | G28.5 |
| Immunogen | Human erythrocyte-rosette-negative tonsillar lymphocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074226 |
Product Specific Information
Specificity: Recognizes a 48 kD Type I glycoprotein belonging to the TNFR superfamily. Expressed on normal or malignant B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells.
Target Information
CD40 is a single-chain glycoprotein and a member of the tumor necrosis factor/nerve growth factor superfamily. It is expressed on all B cells except plasma cells, and also found on epithelial cells, carcinomas, and lymphoid dendritic cells.
CD40 plays a crucial role in immune and inflammatory responses, including:
- T cell-dependent immunoglobulin class switching
- Memory B cell development
- Germinal center formation
The AT-hook transcription factor AKNA regulates CD40 expression, influencing homotypic cell interactions. TNFR2 adaptor protein interacts with CD40 to mediate signal transduction.
CD40-CD40L interaction is essential for amyloid-beta-induced microglial activation, suggesting an early role in Alzheimer’s disease pathogenesis.
Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
Associated Diseases:
- Type 3 Hyper-IgM Immunodeficiency
- CD40 Ligand Deficiency
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
🏷️Thermo Fisher Scientific 상품 둘러보기
동일 브랜드의 다른 상품들을 확인해보세요
Thermo Fisher Scientific
Thermo Fisher Scientific CD40 Chimeric Recombinant Rabbit Monoclonal Antibody (G28.5)
696,000원
Thermo Fisher Scientific
Thermo Fisher Scientific CD34 Chimeric Recombinant Rabbit Monoclonal Antibody (My10)
696,000원
Thermo Fisher Scientific
Thermo Fisher Scientific CD40 Recombinant Mouse Monoclonal Antibody (G28.5)
696,000원
Thermo Fisher Scientific
Thermo Fisher Scientific CD52 Chimeric Recombinant Human Monoclonal Antibody (Campath-1H)
696,000원
Thermo Fisher Scientific
Thermo Fisher Scientific Rituximab Recombinant Human Monoclonal Antibody (10F381 (rituximab))
696,000원
배송/결제/교환/반품 안내
배송 정보
| 기본 배송비 |
| 교환/반품 배송비 |
|
|---|---|---|---|
| 착불 배송비 |
| ||
| 교환/반품 배송비 |
| ||
결제 및 환불 안내
| 결제수단 |
|
|---|---|
| 취소 |
|
| 반품 |
|
| 환급 |
|
교환 및 반품 접수
| 교환 및 반품 접수 기한 |
|
|---|---|
| 교환 및 반품 접수가 가능한 경우 |
|
| 교환 및 반품 접수가 불가능한 경우 |
|
교환 및 반품 신청
| 교환 절차 |
|
|---|---|
| 반품 절차 |
|