Thermo Fisher Scientific MMP2 Polyclonal Antibody
Thermo Fisher Scientific의 MMP2 Polyclonal Antibody는 인간 MMP2 단백질을 인식하는 고품질 Rabbit IgG 항체입니다. Western blot, IHC, ICC/IF, IP 등 다양한 응용에 사용 가능하며, 높은 종간 반응성과 안정적인 액상 형태로 제공됩니다. 연구용으로 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 7 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | – |
| Immunoprecipitation (IP) | 1:100–1:500 | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human MMP2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.33 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792342 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (95%), Rat (95%), Xenopus laevis (81%), Pig (96%), Rabbit (95%), Chicken (85%), Sheep (95%), Bovine (94%).
- Positive Control: PC-3, U87-MG, SK-N-SH, U87-MG conditioned medium, mouse brain, DU145.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading connective tissue components. They share a conserved amino acid sequence in the metal-binding active site region and are inhibited by tissue inhibitors of metalloproteinases (TIMPs). MMPs and TIMPs regulate angiogenesis and tissue remodeling.
MMP2 is synthesized as a 631 amino acid proenzyme, activated by cleavage of the first 80 amino acids, and contains propeptide, catalytic, and hemopexin domains. MMP2 mutations are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP2 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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