Thermo Fisher Scientific SYPL2 Polyclonal Antibody
SYPL2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상형 항체이며, 1 mg/mL 농도. 근육 내 Ca2+ 신호 조절 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide near the carboxy terminus of human SYPL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152294 |
Product Specific Information
- Suggested positive control: human spleen tissue lysate
- PA5-20776 can be used with blocking peptide PEP-0890.
Target Information
SYPL2 (also known as Mitsugumin 29) is a transmembrane protein located at the triad junction in skeletal muscle, sharing homology with the synaptophysin family. It participates in excitation–contraction coupling and plays a role in muscle Ca²⁺ signaling by regulating store-operated Ca²⁺ entry. SYPL2 interacts with the ryanodine receptor (RyR), influencing intracellular Ca²⁺ homeostasis. Co-expression of SYPL2 and RyR may induce apoptotic cell death due to depletion of intracellular Ca²⁺ stores.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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