Thermo Fisher Scientific NMT2 Monoclonal Antibody (OTI1B4), TrueMAB

Thermo Fisher Scientific NMT2 Monoclonal Antibody (OTI1B4), TrueMAB

Applications and Tested Dilution

• Western Blot (WB): 1:2,000
• Immunohistochemistry (Paraffin) (IHC-P): 1:150

Product Specifications

Product Specific Information

• For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
• For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Proteolytic degradation is essential for maintaining appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, stress response, antigen presentation, modulation of receptors and ion channels, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway degrades most cytosolic and nuclear proteins, while others are processed through the vacuolar pathway involving endosomes, lysosomes, and the endoplasmic reticulum.
The 26S proteasome is an ATP-dependent, multisubunit complex (~2.5 MDa) composed of a 20S core and 19S regulatory subunits that recognize ubiquitinated proteins and facilitate unfolding and translocation.
Defects in this pathway are associated with genetic disorders such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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