Thermo Fisher Scientific USP7 Monoclonal Antibody (OTI3D3), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

USP7 (also known as HAUSP) is a ubiquitin-specific protease that removes ubiquitin from its substrates.
It regulates protein stability by deubiquitination, influencing the degradation of cellular proteins.
USP7 acts as an antagonist of Mdm2, the E3 ubiquitin ligase for p53, thereby stabilizing p53 and contributing to tumor suppression.
It also participates in oncogenic pathways through interactions with Myc and E1A, potentially providing an alternative mechanism for protecting cells against oncogenic stress.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.