Thermo Fisher Scientific USP7 Monoclonal Antibody (OTI3D3), TrueMAB
USP7 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 IHC(P) 분석에 적합. 인간 시료에 반응하며, 동결건조 형태로 제공. PBS 기반 완충액에 보존제 없이 8% 트레할로스 포함. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3D3 |
| Immunogen | Full length human recombinant protein of human USP7 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
USP7 (also known as HAUSP) is a ubiquitin-specific protease that removes ubiquitin from its substrates.
It regulates protein stability by deubiquitination, influencing the degradation of cellular proteins.
USP7 acts as an antagonist of Mdm2, the E3 ubiquitin ligase for p53, thereby stabilizing p53 and contributing to tumor suppression.
It also participates in oncogenic pathways through interactions with Myc and E1A, potentially providing an alternative mechanism for protecting cells against oncogenic stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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