Thermo Fisher Scientific JMJD1A Monoclonal Antibody (1E12)

Thermo Fisher Scientific JMJD1A Monoclonal Antibody (1E12)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-15723 targets KDM3A in indirect ELISA, IHC, and WB applications, showing reactivity with human samples.
The immunogen is a purified recombinant fragment of human KDM3A expressed in E. coli.
MA5-15723 detects KDM3A, which has a predicted molecular weight of approximately 147 kDa.

Target Information

JMJD1A is a histone demethylase that specifically demethylates Lys-9 of histone H3, playing a central role in the histone code.
It preferentially acts on mono- and dimethylated H3 Lys-9 residues, with stronger activity on dimethylated forms, and weak or no activity on trimethylated H3 Lys-9.
Demethylation generates formaldehyde and succinate. JMJD1A is involved in hormone-dependent transcriptional activation by recruitment to androgen-receptor target genes, resulting in H3 Lys-9 demethylation and transcriptional activation.
It also participates in spermatogenesis by regulating expression of genes such as PRM1 and TMP1, which are required for sperm chromatin packaging and condensation.
Additionally, JMJD1A contributes to obesity resistance through regulation of metabolic genes like PPARA and UCP1.

Notes

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.