Thermo Fisher Scientific JMJD1A Monoclonal Antibody (1E12)
Human KDM3A 단백질을 인식하는 Mouse IgG1 단클론 항체로, WB, IHC, ELISA 등에 사용 가능. 비결합형 액상 형태로 제공되며, 4°C 단기 보관 또는 -20°C 장기 보관 권장. 연구용 전용 제품으로 인간 시료에 반응.
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Thermo Fisher Scientific JMJD1A Monoclonal Antibody (1E12)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E12 |
| Immunogen | Purified recombinant fragment of human KDM3A expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10986292 |
Product Specific Information
MA5-15723 targets KDM3A in indirect ELISA, IHC, and WB applications, showing reactivity with human samples.
The immunogen is a purified recombinant fragment of human KDM3A expressed in E. coli.
MA5-15723 detects KDM3A, which has a predicted molecular weight of approximately 147 kDa.
Target Information
JMJD1A is a histone demethylase that specifically demethylates Lys-9 of histone H3, playing a central role in the histone code.
It preferentially acts on mono- and dimethylated H3 Lys-9 residues, with stronger activity on dimethylated forms, and weak or no activity on trimethylated H3 Lys-9.
Demethylation generates formaldehyde and succinate. JMJD1A is involved in hormone-dependent transcriptional activation by recruitment to androgen-receptor target genes, resulting in H3 Lys-9 demethylation and transcriptional activation.
It also participates in spermatogenesis by regulating expression of genes such as PRM1 and TMP1, which are required for sperm chromatin packaging and condensation.
Additionally, JMJD1A contributes to obesity resistance through regulation of metabolic genes like PPARA and UCP1.
Notes
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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