Thermo Fisher Scientific Phospho-Nanog (Ser71) Polyclonal Antibody
인간 Nanog 단백질의 Ser71 인산화 부위를 인식하는 토끼 폴리클로날 항체입니다. ICC/IF 및 Dot blot에 사용 가능하며, 단백질 A 및 항원 친화 크로마토그래피로 정제되었습니다. 줄기세포 연구 및 Nanog 관련 신호전달 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:10–1:50 |
| Dot blot (DB) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S71 of human Nanog |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10985504 |
Product Specific Information
This antibody is predicted to react with non-human primate based on sequence homology.
Target Information
NANOG (Nanog homeobox) is a divergent homeodomain protein that regulates pluripotency and differentiation of undifferentiated embryonic stem cells. NANOG mRNA is present in pluripotent mouse and human cell lines but absent from differentiated cells. Human NANOG shares 52% overall amino acid identity with mouse NANOG and 85% identity in the homeodomain region.
Human NANOG maps to gene locus 12p13.31, while mouse NANOG maps to 6 F2. NANOG expression is detected in the inner cell mass of the blastocyst and plays a key role in embryonic stem cell proliferation and self-renewal. Overexpression of NANOG promotes S phase entry and proliferation. NANOG dysfunction is associated with teratocarcinoma and germ cell/embryonal cancers.
Research has shown that NANOG, along with transcription factors such as POU5F1 (Oct-4), Sox2, Klf4, Lin28, and c-Myc, can be used to generate induced pluripotent stem (iPS) cells, providing potential applications in regenerative medicine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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