Thermo Fisher Scientific Phospho-TACC3 (Tyr560) Polyclonal Antibody
TACC3 단백질의 Tyr560 인산화 부위를 인식하는 폴리클로날 항체. Western blot에 적합하며, 인간, 마우스, 랫트 시료에서 반응. PBS/glycerol 완충액 내 액상 형태로 제공되며, -20°C 보관. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TACC3 (Accession Q9Y6A5), corresponding to amino acid residues around phosphorylated Tyr560. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817130 |
Product Specific Information
Antibody detects endogenous levels of TACC3 only when phosphorylated at Tyr560.
Target Information
TACC1 is located on the 8p11 chromosomal region that is amplified in approximately 15% of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1 whose expression is enhanced in most breast cancer tumors.
TACC family members (TACC1, TACC2, and TACC3) map closely to the corresponding FGFR1, FGFR2, and FGFR3 genes on chromosomes 4, 8, and 10.
Since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation.
TACC1 contains a conserved C-terminal region similar to the Drosophila homolog D-TACC, which is necessary for normal spindle function. Mammalian TACC proteins appear to interact with centrosomes and microtubules in a similar manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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