Thermo Fisher Scientific Phospho-RIP3 (Ser304) Polyclonal Antibody
RIP3 단백질의 Ser304 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot에 적합하며, 마우스·랫·비인간 영장류 반응성. 고순도 정제, 액상 형태, -20°C 보관.
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Thermo Fisher Scientific Phospho-RIP3 (Ser304) Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from mouse RIP3 around the phosphorylation site of Ser304 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817128 |
Product Specific Information
This antibody detects endogenous levels of RIP3 only when phosphorylated at Ser304.
Target Information
RIPK3 is a serine/threonine protein kinase belonging to the receptor-interacting protein (RIP) family. It contains a unique C-terminal domain distinct from other RIP members and is mainly localized in the cytoplasm, often colocalized with mitochondria. RIPK3 participates in TNF receptor-I signaling, induces apoptosis, and weakly activates NF-κB. Caspase-8 prevents RIPK3-dependent necrosis by forming a proteolytically active complex with CFLAR, which is essential for its protective function.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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