Thermo Fisher Scientific Syntaxin 1a (STX1A) Monoclonal Antibody (OTI7E2)

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Syntaxin 1 is part of the syntaxin superfamily, a group of nervous system-specific proteins involved in docking synaptic vesicles to the presynaptic plasma membrane.
It contains:

• A single C-terminal transmembrane domain
• A SNARE (Soluble NSF Attachment protein REceptor) domain (H3)
• An N-terminal regulatory domain (Habc)

Syntaxin 1 binds synaptotagmin in a calcium-dependent manner and interacts with voltage-dependent calcium and potassium channels via the H3 domain.
This gene product plays a key role in ion channel regulation and synaptic exocytosis.
Alternatively spliced transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.