Thermo Fisher Scientific Syntaxin 1a (STX1A) Monoclonal Antibody (OTI2F11)

Applications and Tested Dilution

• Western Blot (WB): 1:500

Species Reactivity

• Human
• Mouse
• Rat

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Syntaxin 1 is a member of the syntaxin superfamily, which includes nervous system-specific proteins involved in the docking of synaptic vesicles with the presynaptic plasma membrane.
It contains a single C-terminal transmembrane domain, a SNARE (Soluble NSF Attachment Protein Receptor) domain (H3), and an N-terminal regulatory domain (Habc).
Syntaxins bind synaptotagmin in a calcium-dependent manner and interact with voltage-dependent calcium and potassium channels via the H3 domain.
This gene product plays a critical role in ion channel regulation and synaptic exocytosis.
Alternatively spliced transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.