Thermo Fisher Scientific CD74 (B-Cell Marker) Monoclonal Antibody (CLIP/813)

Applications and Tested Dilutions

Product Specifications

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons: exon 1 encodes the leader peptide, exons 2 and 3 encode the extracellular domains, and exon 4 encodes the transmembrane and cytoplasmic regions.
DRA lacks polymorphisms in the peptide-binding region and serves as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5.
The DR beta chain contains polymorphisms that determine peptide-binding specificity. Hundreds of DRB1 alleles are known, and typing is routinely performed for bone marrow and kidney transplantation.
HLA-DR is expressed mainly on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
The human MHC class II molecules (DR, DQ, DP) bind intracellularly processed peptides, present them to T-helper cells, and play a crucial role in initiating immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.