Thermo Fisher Scientific PSMA Monoclonal Antibody (GCP-05), Alexa Fluor 488
PSMA 단백질을 인식하는 GCP-05 클론의 Alexa Fluor 488 결합 단일클론 항체. 인간 시료에 반응하며 ICC/IF 및 유세포분석에 적합. 499/520 nm 형광 특성, 4°C 암소 보관. 전립선암 연구 및 신경계 표지에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GCP-05 |
| Immunogen | Amino acids 44–750 of human GCPII |
| Conjugate | Alexa Fluor™ 488 |
| Excitation / Emission Max | 499 / 520 nm |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage buffer | PBS |
| Contains | 15 mM sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539535 |
Additional Formats
Product Specific Information
This antibody recognizes the extracellular domain (preferentially in native form) of glutamate carboxypeptidase II (NAALADase, FOLH1, PSMA), an approximately 95–110 kDa transmembrane glycoprotein expressed mainly in tumor neovasculature, nervous system, and jejunum. It is an important prostate tumor marker.
Target Information
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on substrates such as folate and N-acetyl-L-aspartyl-L-glutamate, and is expressed in tissues including prostate, central and peripheral nervous system, and kidney. Mutations may impair intestinal folate absorption, leading to hyperhomocysteinemia. In the prostate, expression is upregulated in cancerous cells, serving as a diagnostic and prognostic indicator for prostate cancer. Alternative splicing produces multiple transcript variants.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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