Thermo Fisher Scientific CD59 Monoclonal Antibody (MEM-43), Alexa Fluor 647
인간 CD59 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, Alexa Fluor 647 형광 표지. 유세포 분석(Flow Cytometry)에 적합하며, CD59 관련 보체 억제 기전 연구에 활용 가능. 4°C 암소 보관, 동결 금지.
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Applications
- Flow Cytometry (Flow): 4 µL per 100 µL whole blood or 10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-43 |
| Immunogen | Thymocytes and T lymphocytes |
| Conjugate | Alexa Fluor™ 647 |
| Excitation / Emission Max | 650 / 671 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539522 |
Additional Formats
- Unconjugated (MA1-19133)
- APC (A15705)
- Biotin (MA1-19504)
- FITC (MA1-19576)
- PE (MA1-19639)
- Custom conjugation available
Product Specific Information
This antibody recognizes a well-defined epitope (W40, R-53) on CD59 (Protectin), an 18–20 kDa GPI-anchored glycoprotein expressed on all hematopoietic cells and widely present in various tissues.
It does not compete with MEM-43/5 and exhibits blocking activity.
Target Information
CD59 (Protectin) is a small (18–20 kDa) GPI-anchored inhibitor of the membrane attack complex (MAC).
It prevents autologous cell lysis by binding complement components C8 and/or C9, inhibiting pore formation.
CD59 also acts as a low-affinity ligand for CD2, contributing to T cell costimulation and signal transduction.
Mutations in CD59 can lead to deficiency syndromes associated with hemolytic anemia, thrombosis, and cerebral infarction.
Multiple alternatively spliced transcript variants of CD59 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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