Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (53-6.7), Alexa Fluor 488

Applications and Tested Dilution

Product Specifications

Additional Available Formats

• Unconjugated
• APC
• FITC
• PE
• Custom conjugation available upon request

Product Specific Information

This antibody recognizes an extracellular epitope of murine CD8α (32–34 kDa; alpha chain of the CD8 antigen).

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family. It plays a key role in T cell signal transduction, differentiation, and activation. CD8 is mainly expressed on T cells as a heterodimer of CD8α and CD8β, functioning as a co-receptor for MHC class I molecules. CD8α is also found as a homodimer on subsets of T cells, NK cells, monocytes, and dendritic cells. Binding of MHC-I/peptide complexes to CD8 triggers recruitment of Lck kinase, promoting lymphokine production and cytotoxic T lymphocyte activation. Activated CTLs are crucial for pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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