Thermo Fisher Scientific Human IL-21 Synthetic Peptide
Human IL-21 중심부 15 아미노산 서열로 구성된 합성 펩타이드. PA5-19981 항체의 블로킹 펩타이드로 사용 가능. 면역조절 사이토카인 연구에 적합하며, 액상 형태로 제공. PBS(pH 7.2) 및 0.1% BSA 포함, -20°C 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the center of human IL-21.
PEP-0105 can be used as a blocking peptide with polyclonal antibody PA5-19981.
Target Information
IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17, and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, resulting in transcriptional activation by Bcl6. Similar to IFN-γ for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and function.
IL-21 plays a role in:
- T cell-dependent B cell differentiation into plasma and memory cells
- Stimulation of IgG production
- Induction of apoptotic signaling in naive B cells
In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4, and RORγt lead to upregulation of IL-23R, supporting Th17 cell maturation and maintenance by IL-23. IL-21 also mediates downregulation of Foxp3.
IL-21 deficient mice are protected from developing colitis, whereas elevated IL-21 levels are observed in colitis models.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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