Thermo Fisher Scientific CACNB4 Polyclonal Antibody
Rabbit polyclonal antibody against human CACNB4. Validated for Western blot and IHC (paraffin). Recognizes human, mouse, and rat. Lyophilized, unconjugated form. Suitable for calcium channel research and epilepsy-related studies.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:4,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 | - |
| Miscellaneous (PubMed) | - | View 2 publications |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal region of human CACNB4 conjugated to blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4 °C for short term. For long-term storage, store at −20 °C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen is homologous in many species including mouse and rat.
- Specificity: CACNB4.
Target Information
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio.
Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing.
The encoded protein plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting, and shifting the voltage dependence of activation and inactivation.
Certain mutations in this gene have been associated with idiopathic generalized epilepsy and juvenile myoclonic epilepsy.
Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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