Thermo Fisher Scientific CACNB4 Polyclonal Antibody
Rabbit polyclonal antibody recognizing CACNB4, validated for WB and IHC. Reacts with human, mouse, and rat. Lyophilized form, reconstitutable in sterile water. Suitable for calcium channel research and related neurological studies.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | – |
| Immunohistochemistry (IHC) | 10–50 µg/mL | – |
| Miscellaneous (PubMed) | – | View 2 publications |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal region of human CACNB4 (Voltage-dependent L-type calcium channel subunit beta-4) conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4 °C for short term. For long-term storage, store at −20 °C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen is homologous in many species including mouse and rat.
- Specificity: CACNB4.
Target Information
This gene encodes a beta subunit of voltage-dependent calcium channels. These channels mediate calcium ion influx upon membrane polarization and consist of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The beta subunit modulates G protein inhibition, increases peak calcium current, controls alpha-1 subunit targeting, and shifts activation/inactivation voltage dependence.
Mutations in this gene are associated with idiopathic generalized epilepsy and juvenile myoclonic epilepsy. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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