ELK Biotechnology MEK-2 (phospho Thr394) rabbit pAb
MEK-2 (phospho Thr394) rabbit pAb는 인산화된 MEK2 단백질을 특이적으로 인식하는 폴리클로날 항체입니다. WB, IHC, IF, IP, ELISA 등 다양한 실험에 활용 가능하며, 세포 내 MAPK 신호전달 연구에 적합합니다. -20°C에서 1년 보관 가능합니다.
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MEK-2 (phospho Thr394) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | MEK-2 (phospho Thr394) rabbit pAb |
| Alternative Names | MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2 |
| Applications | WB; IHC; IF; IP; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunoprecipitation: 2–5 µg/mg lysate ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MEK2 around the phosphorylation site of Thr394 (AA range: 261–310). |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 5606 |
| Human Swiss-Prot No. | P36507 |
| Cellular Localization | Cytoplasm; Membrane; Peripheral membrane protein. Membrane localization is probably regulated by its interaction with KSR1. |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase plays a critical role in mitogen growth factor signal transduction by phosphorylating and activating MAPK1/ERK2 and MAPK2/ERK3. Its activation depends on Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), characterized by heart defects, mental retardation, and facial features similar to Noonan syndrome. Inhibition or degradation of this kinase is also involved in the pathogenesis of Yersinia and anthrax. A pseudogene is located on chromosome 7. (RefSeq, Jul 2008)
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