ELK Biotechnology AMPKβ1 (phospho Ser182) rabbit pAb
AMPKβ1 인산화(Ser182) 부위를 인식하는 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 적합합니다. AMPK 에너지 센서 단백질의 조절 서브유닛을 타겟하며, 세포 내 에너지 대사 연구에 유용합니다. 고농도(1 mg/ml) 및 높은 특이성 제공.
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제품명
AMPKβ1 (phospho Ser182) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PRKAB1; AMPK; 5'-AMP-activated protein kinase subunit beta-1; AMPK subunit beta-1; AMPKb |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Other applications: Not yet tested |
| Immunogen | Synthesized peptide derived from human AMPK beta1 around the phosphorylation site of Ser181 (AA range: 147–196) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 38 kD |
| Gene ID (Human) | 5564 |
| Human Swiss-Prot No | Q9Y478 |
| Cellular Localization | Nucleus, nucleoplasm, cytosol, nucleotide-activated protein kinase complex |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit and non-catalytic beta and gamma subunits. It functions as a key energy-sensing enzyme that monitors cellular energy status. Upon metabolic stress, AMPK becomes activated and phosphorylates acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR), enzymes involved in fatty acid and cholesterol biosynthesis. This beta subunit may positively regulate AMPK activity, and its myristoylation and phosphorylation can influence enzyme activity and subcellular localization. It may also act as an adaptor molecule mediating AMPK complex assembly.
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