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ELK Biotechnology Neu (phospho Tyr877) rabbit pAb
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HER2 인산화 부위(Tyr877)를 인식하는 토끼 다클론 항체로, WB, IHC, IF, IP, ELISA에 사용 가능. 인간 HER2 유래 합성 펩타이드로 면역화. 세포막 및 세포질, 핵에서 발현되는 단백질 검출에 적합. -20°C 보관.
- 판매단위
- pk
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ELK Biotechnology ES1364-100UL Neu (phospho Tyr877) rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES1364-50UL Neu (phospho Tyr877) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Neu (phospho Tyr877) rabbit pAb
제품명
Neu (phospho Tyr877) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ERBB2; HER2; MLN19; NEU; NGL; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340 |
| Applications | WB; IHC; IF; IP; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunoprecipitation: 2–5 µg/mg lysate ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human HER2 around the phosphorylation site of Tyr877 (AA range: 851–900) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 180 kDa |
| Gene ID (Human) | 2064 |
| Human Swiss-Prot No. | P04626 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Isoform 1: Cell membrane (single-pass type I membrane protein), early endosome, cytoplasm (perinuclear region), nucleus. Translocation to nucleus requires endocytosis and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). Isoform 2: Cytoplasm, nucleus. Isoform 3: Cytoplasm, nucleus. |
| Background | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein lacks a ligand binding domain and thus cannot bind growth factors directly. It forms heterodimers with other ligand-bound EGF receptor family members, stabilizing ligand binding and enhancing downstream signaling pathways such as MAPK and PI3K. Amplification or overexpression of this gene is associated with various cancers including breast and ovarian tumors. Alternative splicing results in additional transcript variants. |
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