Thermo Fisher Scientific TRF2 Monoclonal Antibody (4A794.15)

Thermo Fisher Scientific TRF2 Monoclonal Antibody (4A794.15)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• The TRF2 antibody is referred to as both clone 4A794.15 and 4A794 in published literature.
• Recognizes full-length TRF2 and forms lacking both the N-terminal basic domain (B) and the telobox Myb-like C-terminal DNA-binding domain (M).
• Mutant TRF2 forms missing the B and M domains are often referred to as mutant TRF2.
• The epitope is suggested to be in the D or L domain, not in the B or M domain.
• Suggested positive control: HL-60, antigen standard for TERF2 (transient overexpression lysate).

Target Information

TRF2 is a ubiquitously expressed protein involved in telomere length control. It contains a Myb-related DNA binding motif and binds duplex TTAGGG repeats, localizing to all human telomeres in metaphase chromosomes. TRF2 helps protect chromosome ends by maintaining telomere structure and is implicated in preventing cellular senescence. Inhibition of TRF2 has been shown to induce apoptosis in certain mammalian cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.