Thermo Fisher Scientific NOXA Monoclonal Antibody (114C307.1)
Thermo Fisher Scientific의 NOXA 단클론 항체(114C307.1)는 인간, 마우스, 랫트에 반응하며 p53 관련 세포사멸 연구에 적합합니다. Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용 가능. Protein G 정제, 액상 형태, 1.0 mg/mL 농도.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:20–1:1,000 |
| Flow Cytometry (Flow) | 1 µg/million cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 114C307.1 |
| Immunogen | Human Noxa |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1077295 |
Product Specific Information
Suggested positive control: antigen standard for PMAIP1 (transient overexpression lysate), RL-7, Jurkat.
Target Information
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptotic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increases p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacts with anti-apoptotic Bcl-2 family members, resulting in activation of caspase-9. Noxa, like PUMA, localizes to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa have been found in impaired tumor development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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