Thermo Fisher Scientific DAXX Monoclonal Antibody (K.180.3)
DAXX 단백질을 특이적으로 인식하는 단클론 항체로, Western blot 및 면역세포화학(ICC/IF)에 적합합니다. 다양한 종에서 반응하며, Rabbit IgG 형식으로 제공됩니다. 고순도 친화 크로마토그래피 정제 및 안정한 액상 형태로 보관이 용이합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:25 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | K.180.3 |
| Immunogen | Synthetic peptide corresponding to a region surrounding Gln255 of Daxx |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 55 µg/mL |
| Purification | Affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_10977094 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and cytoplasm. It interacts with various proteins such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1.
In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by sequestration into promyelocytic leukemia nuclear bodies or nucleoli.
This protein also associates with centromeres in G2 phase. In the cytoplasm, it may regulate apoptosis. The subcellular localization and function are modulated by post-translational modifications including sumoylation, phosphorylation, and polyubiquitination.
Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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