Thermo Fisher Scientific CHN2 Monoclonal Antibody (E.584.10)
CHN2 단백질을 인식하는 Rat monoclonal antibody로 Western blot에 적합. Human, Mouse, Rat 시료에 반응. Affinity chromatography로 정제된 액상 형태이며, -20°C 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | E.584.10 |
| Immunogen | Full-length recombinant human ß2-Chimerin (CHN2, UniProt ID: P52757-1, amino acids 1–468) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20 °C |
| Shipping Conditions | Wet ice |
| RRID | AB_11002190 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The CHN2 gene encodes a protein belonging to the chimerin family, containing a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain, and an SH2 domain. This protein exhibits GTPase-activating activity regulated by phospholipid binding, and diacylglycerol (DAG) binding induces translocation from the cytosol to the Golgi membrane. It is involved in smooth muscle cell proliferation and migration. Decreased expression is associated with high-grade gliomas and breast tumors, while increased expression is linked to lymphomas. Mutations have been associated with schizophrenia in men. Multiple splice variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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