Thermo Fisher Scientific Phospho-RARA (Ser77) Polyclonal Antibody
Phospho-RARA (Ser77) 폴리클로날 항체로, 인산화된 Retinoic Acid Receptor α의 Ser77 잔기를 선택적으로 검출. Western blot, IHC, ICC/IF에 최적화. 인간, 마우스, 랫트 반응성. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RARA (Accession P10276), corresponding to amino acid residues around phosphorylated Ser77 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2902998 |
Product Specific Information
This antibody detects endogenous levels of Retinoic Acid Receptor alpha only when phosphorylated at Serine 77.
Target Information
RARA is a receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes.
The RXR/RAR heterodimers bind to retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1–DR5.
In the absence of ligand, RXR-RAR heterodimers associate with transcription corepressors that induce histone acetylation, chromatin condensation, and transcriptional suppression.
Upon ligand binding, corepressors dissociate and coactivators are recruited, leading to transcriptional activation.
RARA plays an essential role in retinoic acid-induced germ cell development during spermatogenesis, promoting survival of early spermatocytes and contributing to skeletal growth and matrix homeostasis.
It regulates gene expression in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5 and mediates retinoic acid-induced granulopoiesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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