Thermo Fisher Scientific Phospho-RIP2 (Ser176) Polyclonal Antibody

Thermo Fisher Scientific Phospho-RIP2 (Ser176) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody detects endogenous levels of RIPK2 only when phosphorylated at serine 176.

Target Information

RIPK2 is a serine/threonine kinase involved in cell activation, proliferation, differentiation, and apoptosis. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize, and recruit RIPK2 through CARD-CARD domains. RIPK2 contributes to tyrosine phosphorylation of ARHGEF2 via Src kinase, leading to NF-κB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes Lys-63-linked polyubiquitination by E3 ligases XIAP, BIRC2, and BIRC3. The polyubiquitinated form mediates MAP3K7/TAK1 recruitment to IKBKG/NEMO and induces further Lys-63-linked polyubiquitination, resulting in NF-κB activation. Activated NF-κB translocates to the nucleus to trigger transcription of genes related to immune response, growth, and apoptosis. RIPK2 also promotes BCL10 phosphorylation during T-cell receptor engagement, leading to NF-κB activation.

Usage Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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