Thermo Fisher Scientific EGF Monoclonal Antibody (4E11)
EGF 단백질을 표적하는 Mouse IgG1 단일클론 항체로, WB, ICC/IF, ELISA에 적합합니다. 인간 및 생쥐 시료 반응성이 있으며, 비결합형 액상 형태로 제공됩니다. 세포 성장 신호전달 및 EGFR 연구에 유용한 연구용 시약입니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 | View 1 publication |
| ELISA | 1:10,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4E11 |
| Immunogen | Purified recombinant fragment of human EGF expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, keep at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10984368 |
Product Specific Information
MA5-15606 targets EGF in indirect ELISA, IF, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human EGF expressed in E. coli.
MA5-15606 detects EGF with a predicted molecular weight of approximately 134 kDa.
Target Information
Epidermal Growth Factor (EGF) binds to the EGF receptor (EGFR), a 170 kDa protein kinase, initiating diverse cellular signaling pathways.
Upon activation, EGFR forms homo- or heterodimers with other family members, each triggering distinct downstream cascades via SH2-containing effector proteins.
EGF is widely expressed in kidney, brain, prostate, and salivary glands, acting as a potent mitogenic factor.
It activates major signaling modules including RAS-RAF-MEK-ERK, PI3K-AKT, PLCγ-PKC, and STAT pathways, and may also influence NF-κB signaling.
Defects in the EGF gene are linked to hypomagnesemia type 4, and dysregulation is associated with cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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