Thermo Fisher Scientific ERLIN1 Monoclonal Antibody (OTI4C11), TrueMAB
ERLIN1 단백질을 인식하는 마우스 단클론 항체로, Western blot에 최적화됨. Human, Mouse, Rat 반응성. 동결건조 형태로 제공되며 PBS 버퍼(8% 트레할로스) 내 저장. 세포 내 콜레스테롤 항상성 및 ERAD 연구에 적합.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4C11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 107–346 of human ERLIN1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
ERLIN1 is a component of the ERLIN1/ERLIN2 complex that mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs).
It plays a role in regulating cellular cholesterol homeostasis through the SREBP signaling pathway, binds cholesterol, and may promote ER retention of the SCAP-SREBF complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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