Thermo Fisher Scientific Human ApoE3 Recombinant Protein, PeproTech
인간 ApoE3 재조합 단백질로 지질 대사 연구에 적합. E. coli 발현 시스템에서 생산되며 ≥90% 순도와 낮은 엔도톡신 수준(<1 EU/µg)을 보유. SH-SY5Y 세포 증식 활성 확인. 동결건조 형태로 제공되며 -20°C 보관.
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Applications
Western Blot (WB)
- Assay-dependent
ELISA
- Assay-dependent
- View 3 publications
Functional Assay
- Assay-dependent
In vitro Assay
- View 7 publications
Miscellaneous PubMed
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published species | Human, Mouse |
| Expression System | E. coli |
| Amino acid sequence | MKVEQAVETE PEPELRQQTE WQSGQRWELA LGRFWDYLRW VQTLSEQVQE ELLSSQVTQE LRALMDETMK ELKAYKSELE EQLTPVAEET RARLSKELQA AQARLGADME DVCGRLVQYR GEVQAMLGQS TEELRVRLAS HLRKLRKRLL RDADDLQKRL AVYQAGAREG AERGLSAIRE RLGPLVEQGR VRAATVGSLA GQPLQERAQA WGERLRARME EMGSRTRDRL DEVKEQVAEV RAKLEEQAQQ IRLQAEAFQA RLKSWFEPLV EDMQRQWAGL VEKVQAAVGT SAAPVPSDNH |
| Molecular weight | 34.4 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 90% by SDS-PAGE gel and HPLC analyses |
| Endotoxin concentration | <1 EU/µg |
| Activity | Stimulates proliferation of human SH-SY5Y cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient |
Product Specific Information
- Catalog No. 350-02-1MG is provided as 2 × 500 µg (350-02-500UG).
- Recombinant Human ApoE3 is a 34.4 kDa protein containing 300 amino acid residues.
- Shipped at ambient temperature. For storage, handling and reconstitution details, refer to the lot-specific Certificate of Analysis.
Target Information
ApoE belongs to a group of proteins that bind reversibly with lipoproteins and play an important role in lipid metabolism. These proteins aid lipid solubilization, maintain lipoprotein structural integrity, serve as ligands for receptors, and regulate enzyme activity related to lipid metabolism. ApoE is produced mainly in the liver and brain, and also in other organs. It is a key component of all plasma lipoproteins. Interaction with specific ApoE receptors enables uptake of chylomicron remnants by liver cells, crucial for normal lipid metabolism. ApoE also binds LDL receptors (apo B/E). Defects in ApoE can cause hyperlipoproteinemia type III. ApoE has three major isoforms—E2, E3, and E4—differing by a single amino acid substitution. E3 is the most common, present in 40–90% of the population.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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