Thermo Fisher Scientific Arginase 1 Monoclonal Antibody (GT5811)
Thermo Fisher Scientific의 Arginase 1 Monoclonal Antibody (GT5811)는 인간 및 마우스 반응성을 가진 단일클론 항체로, WB, IHC, Flow, ELISA 등 다양한 응용에 적합합니다. Protein A로 정제된 액상 형태이며, 고농도 보존 가능하고 장기 저장 시 -20°C에서 안정적으로 유지됩니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Arginase 1 Monoclonal Antibody (GT5811)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | View 1 publication |
| Flow Cytometry (Flow) | 1:50–1:200 | - |
| ELISA | 1:1,000–1:10,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT5811 |
| Immunogen | Full length human Arginase 1 recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.26 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787204 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (86%), Rat (86%), Pig (89%), Rabbit (91%), Bovine (90%).
- Positive Control: Huh-7, ARG1-transfected 293T.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, completing the urea cycle. The resulting polyamines are essential for cell proliferation and detoxification of protein degradation byproducts. By degrading arginine, Arginase 1 limits nitric oxide production by depriving NO synthase of its substrate.
In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells. In human, expression is found in blood neutrophils but not in CCR3+ granulocytes. In mice, Arginase 1 is a hallmark of alternatively activated macrophages (M2a). It may also be expressed in myeloid cells infiltrating tumors and is commonly found in hepatocellular carcinomas. Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.