Thermo Fisher Scientific Arginase 1 Monoclonal Antibody (GT5811)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (86%), Rat (86%), Pig (89%), Rabbit (91%), Bovine (90%).
• Positive Control: Huh-7, ARG1-transfected 293T.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, completing the urea cycle. The resulting polyamines are essential for cell proliferation and detoxification of protein degradation byproducts. By degrading arginine, Arginase 1 limits nitric oxide production by depriving NO synthase of its substrate.

In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells. In human, expression is found in blood neutrophils but not in CCR3+ granulocytes. In mice, Arginase 1 is a hallmark of alternatively activated macrophages (M2a). It may also be expressed in myeloid cells infiltrating tumors and is commonly found in hepatocellular carcinomas. Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.