Thermo Fisher Scientific Arginase 1 Monoclonal Antibody (GT825)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (86%), Rat (86%), Pig (89%), Rabbit (91%), Bovine (90%).
• Positive Control: Huh-7, ARG1-transfected 293T.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, the final step in the urea cycle. The resulting polyamines are important for cell proliferation and detoxification processes. By degrading arginine, Arginase 1 limits nitric oxide production by depriving NO synthase of its substrate.

In humans and mice, Arginase 1 is expressed in liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells. In human blood, it is expressed in neutrophils but not in CCR3+ granulocytes. In mice, it is a hallmark of alternatively activated macrophages (M2a). Arginase 1 may also be expressed in tumor-infiltrating myeloid cells and is typically found in most hepatocellular carcinomas. Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.