Thermo Fisher Scientific Periostin Monoclonal Antibody (OTI2F7), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Periostin (PN), also known as osteoblast-specific factor 2 (OSF-2), is a disulfide-linked protein originally identified as an osteoblast-specific factor.
It is a secreted protein that binds heparin and serves as a ligand for αVβ3 and αVβ5 integrins. In preosteoblasts, Periostin functions as a cell adhesion molecule, aiding in osteoblast recruitment, spreading, and attachment.
Periostin is primarily expressed in the lower gastrointestinal tract, aorta, stomach, placenta, uterus, and breast tissues, but is upregulated in epithelial ovarian tumors and overexpressed in breast cancer.
Expression is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGF-β1).
The protein includes a signal sequence, a cysteine-rich domain, four fasciclin-like repeats, and a C-terminal domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.