Thermo Fisher Scientific MTDH Monoclonal Antibody (OTI1E7), TrueMAB
MTDH 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot과 IHC(P) 적용 가능. Human 시료 반응성. 무보존제, 동결건조 형태. 연구용으로 암 전이 관련 단백질 분석에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 70–582 of human MTDH produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
Metadherin (MTDH), also known as LYRIC (Lysine-Rich CEACAM1 co-isolated), is a novel protein localized with tight junction proteins ZO-1 and occludin in polarized epithelial cells.
It is recruited during tight junction maturation rather than serving as a structural component.
MTDH is overexpressed in breast cancer tissues and xenografts, while expression is low in normal breast tissue.
It binds lung vasculature via a C-terminal extracellular domain segment, a mechanism implicated in breast cancer metastasis.
Blocking this domain or inhibiting MTDH expression can reduce metastatic spread.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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