Thermo Fisher Scientific TCF7L2 Monoclonal Antibody (T.473.8)
TCF7L2 단백질을 표적하는 Rabbit 모노클로날 항체로, WB, ICC/IF, IP, ChIP 등 다양한 응용에 적합합니다. Wnt 신호 경로 및 당대사 연구에 활용되며, 고순도 Affinity chromatography로 정제된 액상 형태로 제공됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | 1:50 |
| ChIP assay (ChIP) | 10 µL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | T.473.8 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Leu331 of human TCF4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 36 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10979788 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
TCF7L2, also known as TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. It is involved in glucose homeostasis through the regulation of pro-glucagon gene expression, encoding glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes and are important for beta-cell survival and function. Differential splicing isoforms are expressed in various tissues during cancer progression, and gene targeting studies indicate TCF7L2 is required for maintaining crypt stem cells in the small intestine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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