Thermo Fisher Scientific NAG-1 Monoclonal Antibody (23B3.D2.H5)
인간 NAG-1 단백질의 C-말단을 인식하는 Mouse Monoclonal 항체. Western blot, ELISA, IP에 사용 가능. Protein A로 정제된 액상 항체로 -20°C 보관. GDF-15 연구 및 종간 반응성 분석에 적합.
- 카탈로그번호
- 200-301-B07x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific NAG-1 Monoclonal Antibody (23B3.D2.H5)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| ELISA | 1:2,000 |
| Immunoprecipitation (IP) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 23B3.D2.H5 |
| Immunogen | This Protein A purified antibody was prepared by repeated immunizations with a synthetic peptide corresponding to a region near the carboxy terminal end of human NAG-1 protein. A cysteine residue was added to facilitate coupling to KLH. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.13 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
This antibody reacts with the C-terminus of endogenous NAG-1 protein from human tissues.
A BLAST analysis suggests reactivity with NAG-1 from chimpanzee and macaque (100% homology).
Partial reactivity is expected against rat (86% homology).
Cross-reactivity with NAG-1 from other sources has not been determined.
Target Information
GDF-15 belongs to the TGF-beta cytokine family, which plays an important role during prenatal development, postnatal growth, and tissue remodeling.
It is expressed predominantly in the placenta and, to a lesser extent, in other tissues.
Elevated GDF-15 levels in amniotic fluid and maternal serum suggest roles in gestation and embryonic development.
GDF-15 generally exhibits tumor-suppressive activities and is induced by the p53 pathway.
Serum GDF-15 levels correlate with progression of several tumor types, including colorectal, pancreatic, and prostate cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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