Thermo Fisher Scientific ANKMY2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human ANKMY2 protein. Validated for IHC (Paraffin) with dilution 1:25–1:100. Detects endogenous ANKMY2 levels. Supplied as liquid, 1 mg/mL in PBS with 40% glycerol. For research use only.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested dilution: 1:25–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to residues near the N-terminal of human ankyrin repeat and MYND domain containing 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2635777 |
Product Specific Information
The antibody detects endogenous levels of total ANKMY2 protein.
Target Information
ANKMY2 (ankyrin repeat and MYND domain containing 2) is a 441 amino acid protein that contains three ANK repeats and one MYND-type zinc finger. Encoded by a gene that maps to human chromosome 7p21.1, ANKMY2 is conserved in chimpanzee, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, and Caenorhabditis elegans.
Downregulation of ANKMY2, associated with frequent deletions of human chromosome 7p22.1, indicates that ANKMY2 may play a role in the pathogenesis of natural killer (NK)-cell malignancies. ANKMY2 is also upregulated by enforced expression of Hox11, which functions broadly to hinder hemopoiesis, divert differentiation to an alternative fate, and promote pre-leukaemic states.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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