Thermo Fisher Scientific VAMP2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

PA1-766 detects vesicle associated membrane protein 2 (VAMP-2) from rat and mouse tissues.
It has been successfully used in Western blot, immunofluorescence, and immunoprecipitation procedures.
By Western blot, this antibody detects a 19 kDa protein representing VAMP-2 from rat brain whole protein extract.

The immunogen is a synthetic peptide corresponding to residues M(1) S A T A A T V P P A A P A G E G G(18) C of rat VAMP-2.
This immunizing peptide (Cat. # PEP-101) is available for use in neutralization and control experiments.

Target Information

Vesicle associated membrane proteins (VAMPs), also known as synaptobrevins, are calcium-binding proteins specific to eukaryotes.
VAMPs, together with SNAP-25 and syntaxin, form the core complex of SNARE proteins that interact with NSF and alpha-SNAP.
These membrane-associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane.

The Clostridium tetani neurotoxin is a metalloprotease specific for VAMP.
In Alzheimer’s disease, VAMP levels of all isoforms appear significantly lowered.
VAMP-2 is suggested to be a resident protein of the insulin-sensitive GLUT4 compartment, required for GLUT4 vesicle incorporation into the cell surface in response to insulin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.